Tumour development: Oncogenes in transgenic mice

Development of Transgenic Mice Harboring Ovine Beta Lactoglobulin-Calcitonin Transgene

Mutational patterns in oncogenes and tumour suppressors.

All cancers depend upon mutations in critical genes, which confer a selective advantage to the tumour cell. Knowledge of these mutations is crucial to understanding the biology of cancer initiation and progression, and to the development of targeted therapeutic strategies. The key to understanding the contribution of a disease-associated mutation to the development and progression of cancer, co...

Oncogenes in development.

Realization that the transforming oncogenes (v-onc) of the acutely oncogenic retroviruses are homologous to cellular genes (and were probably derived from them) brought several areas of research together with exciting prospects for advances in virology, carcinogenesis, evolution and development. The proto-oncogenes (c-onc) are likely to be crucially involved in growth regulation and/or differen...

Oncogenes and tumour suppressor genes in first trimester human fetal gonadal development.

Tumour suppressor genes and oncogenes that control proliferation and apoptosis are known to play an important role in embryogenesis, second trimester fetal oocyte loss, adult ovulation, and in adult male testicular degeneration. We have examined tumour suppressor genes, oncogenes and oestrogen receptors during first trimester human gonadal differentiation to investigate their role at this cruci...

Development and identification of Set transgenic mice

As a multifunctional protein involved in numerous biological processes, Set is expressed in several embryonic and adult organs. Furthermore, Set is overexpressed in numerous types of human cancers, including acute myeloid leukemia, breast cancer and pancreatic cancer. The expression of Set in germ cells is involved in gonad development, and the overexpression of Set has been observed in polycys...